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As shown in Figure 6A , GSH levels decreased to 2540% of control cells after AQ-QI or DEAQ-QI treatment, while the intracellular GSSG concentrations did not increase correspondingly, but decreased to approximately 4580% ( Figure 6B )

Standard precautionary principles recommend avoiding use during pregnancy absent compelling medical necessity and informed risk-benefit assessment

10.1016/0022-2836(92)90692-d 74 SheehanD.MeadeG.FoleyV

the 0.5 mg arm not higher doses met the Phase 2b endpoint

Ubiquitination assays comparing *NSD2 PWWP1 mutants were performed similarly, except that SKP1-FBXO22, *NSD2 PWWP1 mutants, and compounds were not incubated separately prior to the start of the reaction